|
KMID : 0359920080270040452
|
|
Korean Journal of Nephrology
2008 Volume.27 No. 4 p.452 ~ p.457
|
|
|
Association of Depression With Inflammation and Cardiovascular Risk Factors in End Stage Renal Disease Patients on Hemodialysis
|
|
Hyun Young-Youl
Ko Gang-Jee
Cho Won-Yong
Kim Hyung-Kyu
Kim Hye-Won
Lee Jae-Won
Choi Hye-Min
Boo Chang-Su
Jo Sang-Kyung
Choi Yoon-Seok
Kim Sun-Chul
Oh Se-Won
Cha Jin-Joo
|
|
|
Abstract
|
|
|
Purpose: Depression is associated with increased inflammation and cardiovascular disease. And in patients with end stage renal disease (ESRD), depression is a common problem and cardiovascular disease is the main cause of death. The aim of this study is to investigate the association of depression with various inflammatory markers and with some cardiovascular risk factors in ESRD patients on hemodialysis
Methods: 53 patients with ESRD on maintenance hemodialysis were divided into depressive symptom (BDI> or =11) group and control (BDI < 11) group by the 21-items Becks depression inventory (BDI). We collected patients characteristics and laboratory measurements by medical records. And then, we measured the levels of IL-10 and TNF-alpha a and analyzed the genotype of IL-10 and TNF-alpha a promoter area.
Results: The levels of TNF-alpha, CRP and ferritin were significantly higher in depressive symptom group (p=0.001, 0.04, 0.02) and IL-10 concentration tended to be lower in depressive symptom group (p= 0.05). The prevalence of left ventricular hypertrophy was higher in depressive symptom group than in the control group (44% vs 9%, p=0.01). GG genotype known as high IL-10 producer was less common in depressive symptom group than in control group (8% vs 36%, p=0.039).
Conclusions: Increased inflammation, high left ventricular hypertrophy prevalence and low ejection fraction were observed in depressive hemodialysis patients. Further prospective study is needed to clarify the role of depression in the development of inflammation and cardiovascular disease in ESRD patients.
|
|
|
KEYWORD
|
|
|
Depression, Hemodialysis, Inflammation, Cardiovascular disease
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|